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dFatp Regulates Nutrient Distribution and Long‐term Physiology in Drosophila
Author(s) -
Richardson Chelsea,
Sujkowski Alyson,
Wessells Robert
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.824.1
Subject(s) - lipid metabolism , drosophila melanogaster , drosophila (subgenus) , lipidomics , biology , mutant , metabolism , fatty acid , transporter , nutrient , cell physiology , physiology , microbiology and biotechnology , lipid droplet , medicine , endocrinology , biochemistry , gene , cell , ecology
Onset and progression of age‐related functional declines are closely regulated by nutrient allocation and usage. Reduced expression in Drosophila fatty‐acid transporter protein ( dFatp ) alters nutrient distribution and lipid metabolism . Heterozygous dFatp mutants ( dFatp mut ) display improvements in multiple aspects of physiology, including lifespan, stress resistance, and mobility. Such flies also have altered lipid metabolism with increased whole‐fly triglycerides and accumulation of lipid droplets in cardiac muscle despite a reduced feeding rate. Lipid accumulation in the heart leads to reduced fractional shortening and cardiac stress tolerance in dFatp mut flies. Endurance training reduces cardiac lipids levels and reverses the cardiac impairments without altering the extended lifespan. Using lipidomics, overexpression, and structure/function analysis, we are currently working to better understand the mechanism of lifespan extension in these mutants.