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Histamine Receptor Blockade Does Not Increase Creatine Kinase Concentrations Following Muscle Damaging Exercise
Author(s) -
Ely Matthew,
Romero Steven,
Sieck Dylan,
Luttrell Meredith,
Halliwill John
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.822.1
Subject(s) - blockade , histamine , medicine , histamine receptor , histamine h1 receptor , creatine kinase , endocrinology , receptor , antagonist
Case studies have documented the use of antihistamines in the hours preceding extensive and unaccustomed exercise that resulted in rhabdomyolysis. Histamine is a known mediator of inflammation caused by tissue damage. It is unknown if blockade of histamine actions during and immediately following muscle damaging exercise increases the severity of injury. Therefore, the purpose of this experiment was to determine if histamine receptor blockade during muscle damaging exercise affected the extent of injury. It was hypothesized that blockade of histamine H 1 + H 2 receptors would increase muscle damage as evidenced by a higher creatine kinase (CK) concentration in the ensuing 72 hrs in a histamine blockade group compared to a control group. Volunteers (n=20, 4F) were randomly assigned to histamine blockade (n=10; 540mg fexofenadine; an H 1 blocker and 300mg ranitidine; an H 2 blocker) or control (n=10; no drug) group. Muscle damage was induced by 45‐min of downhill running (‐10% grade) at a heart rate of ~150 BPM. Blood collected prior to, following, 6, 12, 24, 48, and 72 hrs after exercise was analyzed for CK concentrations. CK concentrations for both groups increased immediately following exercise (mean ± SE; 25.2 ± 4.8 u/L), as well as 6 (48.7 ± 6.9 u/L), 12 (62.2 ± 8.1 u/L), 24 (52.5 ± 8.4 u/L), and 48 (30.0 ± 5.0 u/L) hrs over the pre‐exercise concentrations (17.3 ± 3.3 u/L) (p<0.05). Although there was a slight increase in CK concentrations in the blockade group compared to the control group at 12, 24, 48 and 72 hrs, the mean difference between groups (5.0 ± 10.1u/L) was not significant. Thus, it appears that histamine receptor blockade does not increase the magnitude of muscle damage following moderate intensity eccentric aerobic exercise.