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A physiological model of the hunger response in humans
Author(s) -
Garan Steven,
Preecha Andrew,
Sun Shuzhang,
White Randall,
Schwartz Aaron,
Barakat Rita,
Efe Gizem,
He Puhan,
Tan Steven,
Peng Justin,
Nowak Joshua,
Mehdizadeh Sadaf,
Kadivar Armita,
Brooks George
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.814.12
Subject(s) - arcuate nucleus , leptin , neuroscience , insulin , biology , psychology , nucleus , endocrinology , obesity
The hunger response in humans has been simulated in an quantitative temporal physiological model using the Center for Research and Education in Aging Language (CREAL). CREAL is a language that can be used to describe biological systems from a macro to a molecular scale. The simulation of the hunger response shows the concentration of compounds throughout the model, during a 24 hour period. The release of orexin, which modulates the human hunger response is simulated with respect to insulin, leptin, and gherkin, this is achieved by modeling the neural pathways linking the gut, the arcuate nucleus, and the paraventricular nucleus.