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Vasopressin Infusion During Pregnancy is Associated with Cardiovascular and Metabolic Dysfunction in Offspring
Author(s) -
Sandgren Jeremy,
Scroggins Sabrina,
Santillan Donna,
Pearson Nicole,
Pierce Gary,
Sigmund Curt,
GibsonCorley Katherine,
Santillan Mark,
Grobe Justin
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.810.2
Subject(s) - medicine , endocrinology , offspring , vasopressin , preeclampsia , blood pressure , gestation , pregnancy , intrauterine growth restriction , copeptin , proteinuria , arginine , kidney , biology , genetics , biochemistry , amino acid
Preeclampsia (PreE) is a cardiovascular disorder of late pregnancy characterized by hypertension, proteinuria, renal glomerular endotheliosis, and intrauterine growth restriction, and children born to PreE pregnancies exhibit life‐long increased risk for cardiovascular and metabolic disease. Recently we demonstrated that PreE in humans correlates with a sustained increase in maternal plasma levels of copeptin, a byproduct and marker for arginine vasopressin (AVP), and that PreE can be modeled in mice by chronic infusion of AVP (24 ng/hr, sc) during gestation. We tested the hypothesis that elevated AVP during gestation in C57BL/6J mice would cause increased cardiovascular and metabolic dysfunction in offspring. Adult (8 wk) offspring from pregnancies complicated by AVP exhibited increased blood urea nitrogen (control n=8, 23.6±1.8 vs AVP n=3, 58.3±16.6 mg/dL, P<0.05), serum potassium (6.7±0.3 vs 8.2±0.8 mM, P<0.05), and blood pressure (SBP: n=10, 103±2 vs n=32, 109±1 mmHg, P<0.05), and possibly heart rate (453±5 vs 471±8 BPM, P=0.27). These animals also exhibited increased body mass (control n=10, 18.9±0.7 vs AVP n=32, 20.6±0.5, P<0.05), water intake (control n=9, 2.6±0.1 vs AVP n=9, 3.0±0.2 mL/day, P<0.05) and possibly food intake (3.3±0.1 vs 3.6±0.1 g/day, P=0.24). We conclude that increased risk of cardio/metabolic disease in offspring of PreE pregnancies may result from increased exposure to AVP during gestation.