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Effect of Stress on Glucose Uptake in Skeletal Muscles: Roles of Beta Adrenergic Receptors
Author(s) -
Li Yifan
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.806.6
Subject(s) - glut4 , endocrinology , medicine , skeletal muscle , glucose uptake , receptor , glucose transporter , adrenergic receptor , carbohydrate metabolism , agonist , insulin , biology , chemistry
Emerging evidence indicates mental and physical stresses are the risk factors for metabolic disorders, obesity, and type 2 diabetes. Sympathetic nervous system (SNS) innervates skeletal muscles and regulates various muscle functions, including metabolism. Elevated SNS activity is well‐known in stress responses. However, the role and underlying mechanisms of SNS in glucose metabolism in skeletal muscles in stress remain to be fully understood. In this study, mice received acute or repeated restraint stress. Plasma glucose level was significantly increased during acute stress, which was significantly abolished by type 2 beta adrenergic receptors (β2AR), ICI118551. In mice receiving repeat restraint stress for 10 days, the response of insulin tolerance test (ITT) was attenuated, which was reversed by the pretreatment with ICI118551. Moreover, in vitro, treatments with β2AR agonist, formoterol, increased at low doses but decreased at high doses the translocation of glucose transporter 4 (Glut4) to plasma membranes in skeletal muscle cell line, C2C12. Overall, these data suggest β2AR may be involved in stress‐induced negative effect on glucose uptake in skeletal muscles.