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HOMA MODELING IS SIGNIFICANTLY ASSOCIATED TO THE CUTANEOUS BLOOD PERFUSION RESPONSES OF INSULIN
Author(s) -
La Fountaine M,
Swonger K,
Hobson J,
Bauman W
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.802.7
Subject(s) - medicine , insulin resistance , perfusion , insulin , iontophoresis , vasodilation , microcirculation , endocrinology , prospective cohort study , placebo , cardiology , pathology , alternative medicine , radiology
A deviation from normal in HOMA modeling of β‐cell function and sensitivity (S) are associated with a state of insulin sensitivity or resistance. Iontophoretic delivery of insulin induces endothelial‐mediated vasodilatation and an increase of blood perfusion of the cutaneous microcirculation. The relationship between HOMA models and the cutaneous perfusion responses to insulin is unclear. A prospective trial was performed in otherwise healthy, non‐diabetic men (n=9) and women (n=2). HOMA%β and %S were calculated from fasting blood samples. Iontophoresis with insulin and placebo was performed in the lower leg. Laser Doppler flowmetry characterized peak blood perfusion unit (BPU) responses (%change from BL) to iontophoretic conditions. BPU response of the placebo was subtracted from that of insulin (NetIns). Descriptive statistics were performed to characterize the cohort for demographics, NetIns, HOMA%β and HOMA%S. Separate regression analyses determined the linearity between NetIns and HOMA%β and %S. The cohort was 40±12 years old, 1.73±0.10 meters tall, 79.6±14.4 kg, and a BMI of 25.9±3.5. HOMA%B was calculated to be 168.9±87.2 and %S 53.4±24.6. The NetIns response was 286±264% and had a significant negative association to HOMA%β (R 2 =0.51;p=0.01) and positive association to %S (R 2 =0.40;p=0.02). Our findings demonstrate that the cutaneous microvascular endothelium is adversely affected by changes to peripheral insulin sensitivity and β‐cell function. The deviation from a state of insulin sensitivity to that of resistance may be ascertained by studying the cutaneous microvasculature using iontophoretic methodology.