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Effect of Resveratrol on Cardiovascular and Metabolic Function in Adult Male and Female Offspring Born Intrauterine Growth Restricted
Author(s) -
Shah Amin,
Reyes Laura,
Morton Jude,
Davidge Sandra
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.799.10
Subject(s) - offspring , resveratrol , physiology , medicine , endocrinology , biology , pregnancy , pharmacology , genetics
Background Several studies have shown that intrauterine growth restriction (IUGR) predisposes offspring to develop metabolic and cardiovascular disorders in later life. Resveratrol (Resv) has been shown to improve these disorders in adult male IUGR rat offspring. We aim to identify the ability of Resv to prevent cardiovascular and metabolic dysfunction in female IUGR offspring. Methods: Male and female, control or IUGR rat offspring (born from dams exposed to hypoxia; 11% O 2 in the last third of pregnancy) were fed a high‐fat (HF) diet or a HF diet with Resv (4g/kg of diet) from 3‐12 weeks of age. Metabolic and cardiac functions were assessed using a glucose tolerance test, echo MRI and a Langendorff heart system (ischemia/reperfusion (I/R) injury). Cardiac superoxide and endothelial nitric oxide synthase (eNOS) protein levels were assessed using DHE staining and Western blot. Results: Glucose tolerance was impaired in only male IUGR offspring and improved by Resv. In female IUGR offspring, cardiac power after I/R injury was decreased (Control‐HF 78.67 ± 3.86 vs IUGR‐HF 40.68 ± 11.20 joules.min ‐1 g dry wt ‐1 , P<0.05 ) and improved by Resv (Control‐HF+Resv 73.71±2.11; IUGR‐HF+Resv 76.65 ± 8.59 joules.min ‐1 g dry wt ‐1 , P<0.05). Similar effects were found in male IUGR offspring. In female IUGR offspring, Resv attenuated superoxide and increased eNOS protein levels in cardiac tissue. Conclusion Prenatal hypoxia and postnatal HF diet exacerbate cardiac and metabolic dysfunction in young adults, which may be improved by Resv treatment. Sex differences in susceptibility to metabolic dysfunction, however, need to be further explored.