Premium
EVALUATION OF CARDIO PROTECTIVE ACTIVITY OF WHEAT GRASS AND BIOENHANCING PROPERTY OF COW URINE (WHEAT GRASS FORTIFIED WITH COW URINE) AGAINST DOXORUBICIN INDUCED CARDIOMYOPATHY
Author(s) -
Papasani Madhava,
Akula Annapurna,
Kilari Eswar
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.785.11
Subject(s) - doxorubicin , malondialdehyde , cardiotoxicity , urine , creatine kinase , chemistry , lipid peroxidation , pharmacology , oxidative stress , medicine , toxicity , biochemistry , chemotherapy
Doxorubicin is a widely used as chemotherapeutic agent for various malignancies. However, doxorubicin generates oxygen free radicles that results in cardiotoxicity. Supplementation with wheat grass was proven effective in reducing oxidative stress associated with several ailments. The aim of the current study was to evaluate the potential protective effect of Wheat grass and bio enhancing property of cow urine (Fortified wheat grass that is wheat grass fortified with Cow Urine) against doxorubicin induced cardiomyopathy in male rats. Doxorubicin was administered i.p. for a cumulative dose of 24 mg/kg BW over a period of eight weeks in eight consecutive doses (3 mg/kg BW). Wheat grass 250 and 500 mg/kg, fortified wheat grass 500 mg/kg dose were started one week prior to doxorubicin administration, and were continued with doxorubicin for eight weeks. Wheat grassprotected againstDOX‐induced mortality and signicantly inhibited DOX‐provoked lipid peroxidation that is malondialdehyde (MDA) levels in cardiac tissues. The reductions of cardiac activities of catalase, superoxide dismutase, and reduced glutathione were signicantly mitigated. Pretreatment with wheat grass and fortified wheat grass signicantlyguardedagainstDOX‐inducedriseof creatine kinase (CK), creatine kinase‐MB (CK‐MB), LDH, troponin‐I, C‐RP, SGPT, SGOT, Ca 2+ , serum iron (Fe 3+ ), serum Sodium, Potassium and chloride, Total Cholesterol, Triglycerides, and HDL levels. In conclusion, wheat grass and fortified wheat grass offered significant cardiac protection and healing effect against doxorubicin induced cardiomyopathy in rats.