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Effects of Resveratrol on Contractions of the Rat Tail Artery
Author(s) -
Peuler Jacob,
Stom Sayra,
Phelps Laura
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.783.6
Subject(s) - resveratrol , artery , mesenteric arteries , anatomy , medicine , conductance , uterine artery , endocrinology , chemistry , vascular smooth muscle , smooth muscle , biology , pharmacology , pregnancy , gestation , mathematics , combinatorics , genetics
In 2000, Naderali et. al. reported in Clinical Science (98:537‐43) that resveratrol's direct vasorelaxant effect in vitro (on either adrenergic receptor‐induced or high potassium‐induced vascular smooth muscle contractions) was significantly greater in ring segments cut from mesenteric resistance arteries than from the main uterine conductance artery of female guinea pigs. Since then this important difference has not been confirmed in any other resistance versus conductance arterial tissues, and isolated from the same vasculature perfusing the same organ rather than different vessels perfusing different organs. The most distal and most proximal portions of the notably long ventral tail artery of the laboratory rat are commonly known for their unique structural and functional similarities to other resistance and conductance arteries (respectively) found throughout the rest of the body. Accordingly, we tested for relaxant effects of resveratrol in vitro in adrenergically pre‐contracted rings cut from short segments of the distal and proximal portions of the tail artery from male rats. Its half‐maximally effective concentration values were essentially identical (25±3 versus 27±3 micromolar) in distal versus proximal segments; results which do not confirm a greater relaxant effect of resveratrol in resistance versus conductance arterial tissues. Therefore, what Naderali et. al. previously observed may have been due to some other property that differed between their mesenteric and uterine arterial preparations. Support: MWU Master's Program.