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Anti‐diabetic Effects of Propolis in High Fat Diet Fed‐Streptozotocin‐induced Type 2 Diabetic Rat
Author(s) -
Tang HungWei,
Chan ChingHung,
Lin YiTing,
Huang HuiYu
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.756.7
Subject(s) - endocrinology , medicine , streptozotocin , triglyceride , proinflammatory cytokine , propolis , tbars , chemistry , diabetes mellitus , insulin , cholesterol , lipid peroxidation , oxidative stress , inflammation , food science
Propolis (PPLs) has been indicated the ability of antitumor, antioxidant, anti‐inflammatory, and immunomodulatory. The purpose of this study was to investigate the effects of hypoglycemic and hypolipidemic activities of PPLsin high fat diet fed‐Streptozotocin‐induced Type 2 Diabetic Rat. Five groups of 10 male Sprague‐dawley rats were fed for eight weeks with ( 1 ) control diet, ( 2 ) HF / HFr + STZ with thiazolidinedione ( TZD ), ( 3 ) HF / HFr + STZ ( DM ), ( 4 ) HF / HFr + STZ with 46.88 mg/kg PPLs, ( 5 ) HF / HFr + STZ with 234.4 mg/kg PPLs. PPLs supplementation significantly attenuated the increase blood glucose and insulin. Also decrease HOMA‐IR, the area under the blood glucose curve in OGTT, total cholesterol, triglyceride, TBARS, proinflammatory cytokines (TNF‐α, IL‐1β, and IL‐6), and the expression of fatty acid synthesis related genes ( SREBP‐1 and FAS) in treatment group. In contrast, the mRNA levels of ppar‐α, ppar‐γ were higher in PPLs treated groups than DM group. These datas suggest that PPLs used in this study may have beneficial Anti‐diabetic Effects.