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Dairy administration of Lactobacillus reuteri 263 suppresses body fat synthesis and alters the body composition on high fat diet induced obese SD rats
Author(s) -
Tsao ShuPing,
Lin YiTing,
Huang HuiYu
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.756.6
Subject(s) - lactobacillus reuteri , obesity , body weight , medicine , calorie , fat accumulation , endocrinology , composition (language) , lactobacillus , chemistry , food science , linguistics , philosophy , fermentation
Recent studies have reported the protective effects of probiotics in hypolipidemia and related metabolic disease. The aim of present study was to evaluate the body fat synthesis effect of Lactobacillus reuteri strain 263 (Lr 263) by using high fat diet induced obesity animal model Sprague‐Dawley rats. Sprague‐Dawley rats were randomly assigned into five groups including one normal diet group (Control; C) and four high‐calorie diet‐induced obese groups. Each group was given either ddH2O (Obesity; Ob), low dose of Lr 263 (1X‐Lr 263, 2.1 × 109 cells / kg BW), the normal dose of Lr 263 ( 2X‐Lr 263, 4.2 × 109 cells / kg BW), or high dose of Lr 263 (5X‐Lr 263, 10.5 × 109 cells / kg BW). After 8 weeks, body weight, food intake, food utilization rate, body composition, body fat content and blood serum level were measured. The result found that adminstration Lr 263 can effectively reduce food utilization, decreased body and fat weight, alter body composition profile in obese rat. In conclusion, oral Lr 263 may have beneficial anti‐obesity effects in obese rats. Thus, these results indicated that Lactobacillus reuteri 263 may have a potential for the treatment of obesity and related disease.