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Effects of soybean embryo on lipid metabolism of non‐alcoholic fatty liver disease in C57BL/6 mice fed a high cholesterol and high fat diet
Author(s) -
Hong Jihye,
Kim HyunSook
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.755.21
Subject(s) - medicine , endocrinology , fatty liver , cholesterol , hypertriglyceridemia , lipid metabolism , adipose tissue , weight gain , embryo , obesity , chemistry , biology , triglyceride , body weight , disease , microbiology and biotechnology
NAFLD is considered the most common liver disease. NAFLD is often referred to the risk factors of obesity, type 2 diabetes and hypertriglyceridemia. In this study, we investigated the effects of soybean embryo on the lipid metabolism of mice fed high cholesterol and high fat diets. Mice were randomly allocated into 4 groups that were fed different diets: the normal diets (ND); High cholesterol and high fat diets (HD); HD with 10% and 20% Soybean embryo (10SE‐HD and 20SE‐HD). Body weight gain in the mice fed on the HD (15.15±4.09g) was significantly higher than in the ND (6.44±1.22g). However, soybean embryo supplementation (10SE‐HD; 8.98±0.88g, and 20SE‐HD; 7.98±2.5g) significantly reduced body weight gain, as compared with those fed on the HD (p<0.05). Liver weight significantly increased in the HD (7.99±1.598g) compared to the ND (5.09±1.018g). On the other hand, liver weight decreased in a dose dependent manner in all experimental groups (6.61±1.322g , 5.43±1.086g). Abdominal and epididymis adipose tissue weights of the HD were of the highest value: 0.66±0.016g and 2.29±0.063g, and they decreased by soybean embryo supplementation. Total cholesterol and triglycerides were significantly lower in the experimental groups (119.50±8.71mg/dl, 130.07±9.48mg/dl and 111.76±9.38mg/dl, 101.27±11.16mg/dl) than that in the HD (126.45±16.65mg/dl, 202.16±25.62mg/dl). The fasting blood glucose in the HD (344.29±64.37mmol/L) was significantly higher than that in the ND (119.28±13.96mmol/L), and it significantly decreased in all the experimental groups (198.71±23.34mmol/L, 172.86±61.28mmol/L). These results suggest that supplementation with soybean embryo can positively mediate the lipid metabolism of the liver and blood in C57BL/6 mice.