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Beneficial Effects of Citrus Based Mixture Drinks on Behavior of Restraint‐Stressed Rat
Author(s) -
Kim DanBi,
Shin GiHae,
Oh JiWon,
Kim JaeMin,
Kim YoungHyun,
Lee JinHa,
Lee Jong Seok,
Park InJae,
Cho Ju Hyun,
Lee OkHwan
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.755.2
Subject(s) - diazepam , stressor , medicine , endocrinology , defecation , depression (economics) , adrenal gland , physiology , anesthesia , psychiatry , economics , macroeconomics
Recent studies have been reported about association between stress and depression. Stressful life events lead to abnormal changes in mental ability and ethology that impairs its function to appropriately regulate physical and behavioural responses to subsequent stressors. In this study, we investigated the beneficial effect of citrus based mixture beverages (CBMDs; CBMD1&CBMD2) on restraint stress‐induced behavioral alterations. The ratswere fed with various concentration (33, 100, 300 mg/kg) of CBMDs or diazepam (positive control, 0.5 mg/kg) for 4 weeks. For the last day (day 28) following 24 hr of restraint stress. The weight of spleen and adrenal gland from the all groups showed no significant differences. Whereas, the weight of liver from the oral administration of CBMDs (300 mg/kg) group showed significant differences. In the treadmill exercise, CBMDs and diazepam groups group rat showed significant increase in movement distance, as well as decrease the time spent in operating time of electrode plate and number of touch electrode plate. These results suggest that CBMDs can inhibit the restraint‐stress induced depression in animal model.