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Effects of Maternal Vitamin D Deficiency During Pregnancy on the Long‐Term Metabolic Health of Offspring
Author(s) -
Belenchia Anthony,
Rosenfeld Cheryl,
Johnson Sarah,
Peterson Catherine
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.754.7
Subject(s) - offspring , pregnancy , obesity , weaning , physiology , medicine , endocrinology , biology , vitamin d and neurology , gestation , genetics
Evidence is mounting for a developmental origin of health & disease link between maternal (mat) nutrition during pregnancy and offspring risk of obesity/metabolic disorders (MD) later in life. The bioactive form of vitamin D (vitD), calcitriol, and its receptor are involved in adipose tissue (AT) development/function and other metabolic processes. The viable yellow Agouti ( A vy ) mouse is prone to obesity and MD. Coat colors of A vy mice range from brown (Y 0 ) to yellow (Y 5 ); w/ yellow mice typified by obesity and MD.Our goal was to determine if mat vitD deficiency during pregnancy affects the development of obesity and related MD. Before pairing with male A vy /a mice for breeding, female C57BL/6 mice were fed either vitD deficient or control (AIN‐93G) diet for 4 wks & through pregnancy. Yellow male offspring (Y 4 ‐Y 5 )and controls (black) were weaned at 3 wks of age onto control or high fat diet (HFD). Body weight (BW) was measured weekly. Energy balance was measured by indirect calorimetry at 14 wks of age. Glucose disposal was determined by insulin tolerance test at 19 wks of age. Perigonadal (PGAT) and subcutaneous (SQAT) AT, brown AT, and liver were taken at 20 wks of age for histology & gene expression analyses. Mice born to vitD deficient dams weighed less at weaning (10.12g[n=16] v. 10.72g[n=13];p=0.026) independent of coat color. There were no differences in BW between mat diet groups or 20 wk weight gain, when controlling for coat color and offspring diet, at any other time point. VitD deficiency may however predispose offspring to low birth weight, which has been associated with risk of obesity.