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Low‐Lycopene Tomato Powder Alters Prostate Biology in TRAMP Mice
Author(s) -
Conlon Lauren,
Wallig Matthew,
Erdman John
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.753.13
Subject(s) - tramp , lycopene , prostate cancer , carcinogenesis , prostate , androgen , transgene , androgen receptor , adenocarcinoma , medicine , genetically modified mouse , testosterone (patch) , endocrinology , biology , cancer , cancer research , andrology , hormone , carotenoid , biochemistry , gene
The Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model develops and progresses through all stages of carcinogenesis. We, (Zuniga et al., Cancer Prev. Res. 2013) previously demonstrated a high lycopene tomato powder (TP) was effective in reducing carcinogenesis in the TRAMP model. The objective of the current study was to determine if a low‐lycopene TP (20 fold less than previously tested) impacted carcinogenesis and androgen biology at 3 time points. 8‐week‐old male C57BL/6 X FVB TRAMP mice were randomized to consume either an AIN‐93G + 10% TP diet (N=90) or the AIN‐93G control diet (N=88) and assigned to one of three sacrifice ages: 12 (N=59), 16 (N=60), or 20 (N=59) weeks. There was no difference between diets in overall cancer incidence at each time point. TP significantly increased serum testosterone (p=0.01) and expression of prostatic androgen receptor in high‐grade PIN lesions (p=0.01) at 20 weeks of age compared to the control, suggesting an interaction between tomato components and androgen status in pre‐neoplastic prostate tissue. The results suggest that lycopene content of TP is a crucial modulator of PCa in TRAMP mice. We have shown that a low‐lycopene TP is ineffective in reducing carcinogenesis in the TRAMP model. Support was provided by USDA Hatch grant #ILLU‐971‐348 and UIUC Margin of Excellence Research award.