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PNPLA3 Variants Are Associated with Obesity and Interact with Meat and Dairy Intake in Hispanic and Non‐Hispanic White Americans
Author(s) -
Lin Ning,
Smith Caren,
FrazierWood Alexis,
Parnell Laurence,
Noel Sabrina,
Maras Janice,
Lee YuChi,
Ma YiYi,
Hou RuiXue,
Allison Matthew,
Averill Michelle,
Rotter Jerome,
Tucker Katherine,
Ordovas Jose,
Lai ChaoQiang
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.750.8
Subject(s) - waist , obesity , medicine , white meat , waist–hip ratio , single nucleotide polymorphism , circumference , biology , genotype , food science , genetics , gene , geometry , mathematics
Our aim was to investigate the association of the patatin‐like phospholipase domain containing 3 (PNPLA3) variants with obesity, and their interactions with meat and dairy intakes. Associations and gene by diet interactions with meat and dairy intakes on BMI, waist and waist‐hip ratio (WHR) were tested first in the Boston Puerto Rican Health Study (BPRHS, n=1284), then replicated in the Genetics of Lipid Lowering Drugs and Diet Network Study (GOLDN, n=820), and in Hispanic and non‐Hispanic white participants from the Multi‐Ethnic Study of Atherosclerosis (MESA, n=3495). Nineteen SNPs were associated with BMI, and 13 with waist circumference in the BPRHS. Major allele carriers of rs9625963 had greater BMI (Δ=2.6) and waist circumference. High intake of meat and dairy foods interacted with rs9625963 toward larger waist. The variant showed the same trend of association, but was not significant in GOLDN. In the MESA non‐Hispanic whites, rs9625963 interacted with meat and dairy intake for obesity traits. Our results suggest PNPLA3 variants contribute to obesity risk, especially when combined with high intake of meat and dairy intake.