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Saturated Fatty Acids Differentially Affects Adipocytes and Muscle Cells
Author(s) -
Li Yi,
Gonzalez Trevor,
Fernandez Claudia
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.750.7
Subject(s) - chemistry , microbiology and biotechnology , medicine , biology
Obesity and obesity related type 2 diabetes have become serious health issues in the US and worldwide. It is certain that the human genetic coding cannot been changed so dramatically by evolution during such a short period of time. Environmental factors including diets may play an important role in developing obesity/type 2 diabetes. Since adipose and muscle tissues are significantly affected in individuals with obesity, adipocytes and muscle cells were cultured in the conditions to mimic hyperlipidemia situations that happen during the development of obesity. We have observed that saturated fatty acids at high concentrations differentially affects adipocytes and muscle cells. The saturated fatty acid palmitic acid damages muscle cells and induces muscle cell death while causing more lipid accumulation in adipocytes. Polyunsaturated fatty acid linoleic acid also causes more lipid accumulation in adipocytes but it does not damage muscle cells. A few new candidate genes that are regulated by a saturated fatty acid in muscle cells have been identified by cDNA microarray. Further studies will be conducted to explore the mechanisms at the molecular level.