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Correlations of Serum Persistent Organic Pollutants with Regional Fat Distribution Measured by Dual‐Energy X‐ray Absorptiometry
Author(s) -
zong geng,
Grandjean Philippe,
Sun Qi
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.747.10
Subject(s) - chlordane , dieldrin , trunk , zoology , chemistry , body mass index , population , medicine , pesticide , biology , environmental health , ecology
Study Aim: We analyzed correlations of circulating persistent organic pollutants (POPs) with regional fat mass (FM) distribution in US residents. Method: A total of 3305 participants (蠅20 years) from the National Health and Nutrition Examination Survey 1999‐2004 were analyzed. Pearson correlation coefficients (r) between POPs with detection rate >70% and regional fat mass percentages (FM%) of whole body, trunk and leg were calculated after multivariate adjustment of age, sex, ethnicity, education, physical activity,smoking status,and alcohol consumption. Bonferroni correction of P values was applied for multiple comparisons. Results: Overall, 11 out of the 22 POPs were significantly correlated with at least one of FM% variables. Dieldrin and 1,2,3,4,6,7,8‐hpcdd were positively correlated with fat mass, whereas highly‐chlorinated PCB congeners, including PCB138, PCB153, PCB169, PCB170, PCB180, PCB187, PCB194, PCB196, and PCB199 were inversely correlated with fat mass. However, p,p'‐DDE was not associated with regional fat distribution in the overall population. Patterns were similar when absolute FM variables were analyzed, with fewer significant correlations observed. Conclusion These findings showed that the overall pattern of correlations with body fat distribution varied for different POPs.Pollutants DetectionRates N TotalFat % Trunkfat % Legfat % Oxychlordane 85% 1604 ‐0.05 ‐0.05 ‐0.06 Trans‐nonachlor Chlordane 93% 1797 ‐0.04 ‐0.03 ‐0.07 Total Chlordane## 100% 1814 ‐0.07 ‐0.07 ‐0.08 Dieldrin 78% 933 0.19* 0.21* 0.10 β‐HCH 79% 991 0.08 0.09 0.03 PCB074 76% 2368 0.02 0.01 0.00 PCB099 71% 2345 ‐0.02 ‐0.02 ‐0.02 PCB118 79% 2370 0.03 0.04 ‐0.01 PCB126 82% 2131 0.02 0.04 ‐0.04 PCBs with >=5 Chlorines## 100% 2402 0.02 0.03 ‐0.03 PCB138 84% 2368 ‐0.07 ‐0.08* ‐0.07 PCB153 87% 2369 ‐0.15* ‐0.15* ‐0.14* PCB169 79% 2130 ‐0.27* ‐0.26* ‐0.24* PCBs with 6 Chlorines## 100% 2398 ‐0.16* ‐0.16* ‐0.15* PCB170 80% 2305 ‐0.22* ‐0.23* ‐0.19* PCB180 87% 2369 ‐0.27* ‐0.27* ‐0.23* PCB187 76% 2370 ‐0.17* ‐0.18* ‐0.14* PCBs with 7 Chlorines## 100% 2378 ‐0.25* ‐0.25* ‐0.21* PCB194 78% 1545 ‐0.26* ‐0.26* ‐0.20* PCB196 76% 1561 ‐0.23* ‐0.24* ‐0.17* PCB199 78% 558 ‐0.30* ‐0.30* ‐0.26* PCBs with 8 Chlorines## 100% 1565 ‐0.30* ‐0.31* ‐0.24* Total PCB## 100% 2378 ‐0.15* ‐0.17* ‐0.12* p,p'‐DDE 100% 1814 ‐0.01 ‐0.02 ‐0.02 1,2,3,6,7,8‐hxcdd 78% 2137 ‐0.03 ‐0.03 ‐0.02 1,2,3,4,6,7,8‐hpcdd 90% 2128 0.06 0.09* 0.00 1,2,3,4,6,7,8,9‐ocdd 84% 2097 0.04 0.05 0.01 Total Dioxins## 100% 2164 0.05 0.06 0.02 1,2,3,4,6,7,8‐hpcdf 78% 2039 ‐0.07 ‐0.07 ‐0.05