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Adipokines as Mediators of Bone Density in Overweight/Obese Postmenopausal Women After 6‐Month Weight Loss Program
Author(s) -
Jafarinasabian Pegah,
Chi YiChih,
Ilich Jasminka
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.738.4
Subject(s) - medicine , adiponectin , endocrinology , adipokine , leptin , osteocalcin , bone mineral , bone density , bone remodeling , overweight , weight loss , body mass index , lean body mass , obesity , insulin resistance , osteoporosis , body weight , chemistry , biochemistry , alkaline phosphatase , enzyme
It is not clear how distribution of adipose and lean tissue affects bone mineral density (BMD) and what are the consequences of weight loss on BMD and bone turnover markers. Leptin/adiponectin have been studied as mediators of changes in body composition and bone outcomes. Our objective was to examine the interrelationship of leptin/adiponectin with BMD and bone biomarkers at baseline and after 6 months of weight loss. 189 healthy women were enrolled (BMI=32.0±5.8kg/m 2 , age=55.7±4.4y) and consumed hypocaloric diets for 6 months. Anthropometrics, BMD, serum leptin, adiponectin, 25(OH) D, and bone markers (serum osteocalcin, NTx and urine CTx) were measured at baseline and after 6 months. Dietary/activity records were assessed at those times too. Calculations included partial correlations adjusted for confounders (age, BMI, physical activity, dietary calcium, vitamin D and serum 25(OH)D) and RMANOVA for changes over time ( P <0.05). Leptin was positively correlated with forearm BMD at baseline. Adiponectin showed positive correlation with osteocalcin. After 6 months, participants lost 6.6% and 9.8% of body weight and fat, respectively. Leptin decreased; adiponectin increased significantly. BMD decreased in femoral neck, femur and forearm; significantly only in forearm. NTx decreased significantly; other markers did not change. Leptin was significantly correlated with forearm, total body and femur BMD before and after adjusting for confounders, suggesting that it may play role in bone health independently of body weight/fat. In conclusion, 6 months weight loss resulted in increased adiponectin and decreased leptin, the latter possibly explaining the slight bone loss.