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Assessing Nutritional and Vitamin D Status of Postmenopausal Obese and Osteosarcopenic Obese Women
Author(s) -
Inglis Julia,
Kelly Owen,
Ilich Jasminka
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.738.2
Subject(s) - medicine , osteopenia , vitamin d and neurology , sarcopenia , endocrinology , osteoporosis , obesity , postmenopausal women , vitamin d deficiency , bone mineral
Osteosarcopenic obesity (OSO) is newly identified syndrome which reconciles osteopenia/osteoporosis with sarcopenia and adiposity. Neither complete diagnostic criteria nor full clinical characteristics of this syndrome are defined or understood. Our objective was to examine various nutritional parameters in women with OSO and compare them to obese‐only (OB, without sarcopenia or osteopenia) women. 225 obese postmenopausal women were evaluated for bone, muscle and fat mass by iDXA to identify osteopenia/osteoporosis, sarcopenia and obesity (body fat>30%). OSO was identified in 37 women who were compared to n=53 OB women. Diet and physical activity were assessed as well. Fasting serum vitamin D (25(OH)D) was analyzed by ELISA. Women with OSO had significantly lower calcium (930±469 vs 1293±667 mg/day) and vitamin D, but higher protein (76.1±17.6 vs 74.3±18.1g/day) and energy intake. Their habitual activity was also significantly higher (7.9±4.8 vs 5.9±5.8 hr/week). 25(OH)D, although in an adequate range, was significantly lower in OSO than in OB women (78.8±71.8 vs 130.1±108.4nmol/L); all p<0.05. Although women with OSO were significantly younger and had higher protein and energy intake, and higher level of sustained habitual activity, compared to OB women, their bone and muscle profile was inferior, resulting in the OSO diagnosis. The OB women had higher calcium and vitamin D intake, as well as better vitamin D status, possibly contributing to more favorable bone and muscle profile. Future research is warranted to investigate OSO syndrome and subsequent therapeutic measures for prevention/treatment, as these findings suggest it is a complex condition.