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Association Between Phosphorus Intake and Bone Health in the NHANES Population
Author(s) -
Cho Susan,
Lee Albert
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.736.8
Subject(s) - medicine , quartile , national health and nutrition examination survey , osteoporosis , confidence interval , vitamin d and neurology , bone mineral , odds ratio , dietary reference intake , population , phosphorus , endocrinology , zoology , physiology , nutrient , environmental health , biology , chemistry , ecology , organic chemistry
The objective of this study is to provide reliable estimates of independent associations between intakes of phosphorus (P) and bone mineral content (BMC) and bone mineral density (BMD), as well as the odds ratio (OR) of osteoporosis with quartiles of P intake adjusted for covariates. Data came from males and females aged 13‐99 years who participated in the 2005‐2010 NHANES dietary survey, which includes a representative sample of the non‐institutionalized population of the United States. Our analysis shows that higher calcium (Ca) intake levels are associated with higher P intake and that dietary Ca:P ratios (0.51‐0.62, with an adult population mean of 0.60) were adequate in all age/gender groups. We adjusted for age, gender, BMI, andintakes of calcium, protein, total dairy foods, and vitamin D. Flags were used to denote use of supplemental Ca, vitamin D, and multivitamins/minerals. High consumption of P was positively associated with BMC in female teens (Q4 vs. Q1: BMC, 30.9±1.09 vs. 29.0±0.49 g, P=0.001). High intake of dietary P was also positively associated with BMC and BMD and with reduced risk of osteoporosis in adults older than 20 years (Q4 vs. Q1: OR of osteoporosis, 0.55 [95% confidence interval, 0.39, 0.79] vs. 1.00, P=0.001; BMC, 37.5±0.39 vs. 36.70±0.11 g, P=0.004; BMD, 0.986±0.004 vs. 0.976±0.002 g/cm 2 , P=0.03). The data support our hypothesis that high P intake not only has no adverse effect on bone metabolism in populations with adequate Ca intake, but also is associated with improved bone parameters in some age/gender groups.