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Dietary Fiber Intake and Cardiometabolic Conditions among Adult Survivors of Childhood Cancer: A Report from the St. Jude Lifetime Cohort Study
Author(s) -
Jia Yinan,
Zhang Fang Fang,
Ojha Rohit,
Lanctot Jennifer,
Chemaitilly Wassim,
Krull Kevin,
Hudson Melissa
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.736.25
Subject(s) - medicine , dyslipidemia , waist , odds ratio , insulin resistance , calorie , quartile , metabolic syndrome , cohort , confidence interval , obesity , cohort study , endocrinology
Background Childhood cancer survivors experience high risk of dyslipidemia, insulin resistance, hypertension, and obesity in young adulthood. A high‐fiber diet is associated with reduced risk of cardiometabolic conditions but it remains unclear whether such a diet can decrease cardiometabolic morbidity in childhood cancer survivors. Methods: For 2,571 young adult survivors of childhood cancer (mean ± SD for age = 32.6 ±8.3 years) in the St. Jude Lifetime Cohort Study, self‐reported dietary intake was assessed using the Block food frequency questionnaire. Systematic medical assessments included measurements of blood pressure, weight, height, waist circumference, serum fasting lipids, glucose, and insulin. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) after adjusting for age, sex, race/ethnicity, family income, total energy intake, physical activity, smoking, alcohol consumption, and dietary patterns. Results: The mean dietary intake of fiber was 8.5 g/day per 1,000 kcal calories, substantially lower than the recommended intake(14 g/day per 1,000 calories). Compared to survivors in the lowest quartile of fiber intake, those in the highest quartile had 30‐40% lower odds of prevalent dyslipidemia (OR=0.69, 95%CI: 0.51‐0.95, P trend =0.02), hypertension (OR=0.65, 95%CI: 0.47‐0.90, P trend =0.007), insulin resistance (OR=0.62, 95%CI: 0.45‐0.85, P trend =0.006), and metabolic syndrome (OR=0.61, 95%CI: 0.42‐0.87, P trend =0.03). Conclusions High dietary intake of fiber was inversely associated with the prevalence of cardiometabolic conditions among young adult survivors of childhood cancer.