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Association between fructose, uric acid and blood pressure
Author(s) -
Kuhnle Gunter,
Tasevska Natasa,
Khaw KayTee
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.736.21
Subject(s) - fructose , uric acid , blood pressure , medicine , endocrinology , hyperuricemia , sucrose , chemistry , food science
Sugars, and in particular fructose, consumption has been associated with increased systolic and diastolic blood pressure (BP), mediated by increased serum uric acid concentration, which interferes with the renin‐angiotensin mechanism and inhibits nitric oxide release from endothelial cells. Uric acid can also increase sodium sensitivity. Investigating associations between dietary sugars and health endpoints is difficult because of measurement error in self‐reported intake. Dietary biomarkers may help us elucidate true associations. We have assessed total sugars and total fructose intake (including fructose from sucrose) in a cross‐sectional analysis of 1366 participants (624 men, 742 women), 39 – 77 years of age, of the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC) study using 7‐day diaries and sucrose and fructose measured in spot urines, as biomarkers of sugars intake. Other study measurements include serum uric acid and BP. Associations were investigated using linear regression analyses with log‐transformed variables, stratified by sex and adjusted for age and BMI. Urinary concentrations were adjusted by specific gravity. Total sugars consumption (mean ± SD) was 111.7 ± 40.3 g/d, of which 44.3 ± 17.9 g/d was total fructose. Serum uric acid was 344 ± 66 µM. Serum uric acid concentration was not associated with systolic BP in men and women. Intake of total sugars and total fructose assessed by 7‐d diary or biomarker was not significantly associated with serum uric acid or with BP. Our results do not support an association between fructose intake and increased BP.Adjusted (age, BMI) systolic BP mm Hg (mean, 95% CI) by quintile of total fructose intake in 624 men and 742 women of EPIC Norfolk. Intake was measured by biomarker (urinary fructose) and 7DD (adjusted for total energy intake).Men (n=624) Women (n=742) Intake Biomarker 7DD Biomarker 7DD Q1 137.4 (136.3; 138.6) 136.9 (135.9; 138.0) 132.2 (131.0; 133.5) 131.2 (129.9; 132.6) Q2 136.7 (135.6; 137.8) 137.1 (135.8; 138.3) 132.7 (131.4; 134.0) 131.8 (130.5; 133.1) Q3 136.9 (135.7; 138.0) 137.1 (135.9; 138.3) 132.5 (131.3; 133.8) 133.5 (132.2; 134.8) Q4 137.4 (136.2; 138.5) 136.8 (135.6; 138.1) 132.3 (131.0; 133.6) 132.2 (130.8; 133.5) Q5 137.0 (135.8; 138.2) 137.5 (131.7; 132.9) 131.8 (130.3; 133.2) 132.9 (131.7; 134.0)