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Post‐Prandial Changes in Bone Turnover after High Saturated Fat Challenge Meals
Author(s) -
Rogers Tara,
Demmer Elieke,
Rivera Nancy,
Gertz Erik,
Zivkovic Angela,
Smilowitz Jennifer,
German J,
Van Loan Marta
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.734.2
Subject(s) - n terminal telopeptide , postprandial , bone remodeling , bone resorption , palm oil , medicine , food science , fatty acid , endocrinology , zoology , chemistry , osteocalcin , alkaline phosphatase , biology , biochemistry , insulin , enzyme
Biomarkers of bone turnover fluctuate over the course of a day; these fluctuations are exaggerated with food intake. The effect of foods with differing fatty acid profiles on this phenomenon is unknown. We compared bovine milk saturated fatty acids (SFA) to plant‐based SFA on post‐prandial bone metabolism in overweight/obese subjects. Adult subjects (n=20) participated in a randomized controlled trial, consuming 2 isocaloric high fat meals (dairy cheese sandwich vs. vegan sandwich plus palm oil) separated by a 1‐2 week washout period. Blood samples were collected at baseline, 1, 3, and 6 hrs post‐prandial. Bone resorption marker C‐terminal telopeptide of type 1 collagen (CTx) and bone formation marker cross‐linked C‐telopeptide of type 1 collagen (C1CP) were measured by ELISA. Spearman's Correlation analyses showed that C1CP and CTx were significantly correlated at baseline for both treatments (dairy: r s =0.585, p=0.007; palm oil: r s =0.630, p=0.003). These correlations remained significant at all time points for palm oil, but not dairy, suggesting a potentially more potent effect of dairy SFA. However, ANOVA revealed no significant effects of time or treatment on C1CP. CTx significantly decreased from baseline to 3 hrs after both dairy (p<0.0001) and palm oil (p<0.01), but there was no significant treatment effect. Differences in SFA composition between dairy and palm oil did not affect the postprandial response of CTx and C1CP in this study. Funding: National Dairy Council