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Milk vs Soybean Polar Lipids as Emulsifier: Faster Postprandial Lipid Metabolism through Greater Emulsion Lipolysis
Author(s) -
Lecomte Ma,
Bourlieu Claire,
Cheillan David,
Geloen Alain,
Laugerette Fabienne,
Michalski MarieCaroline
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.734.14
Subject(s) - chylomicron , lipolysis , postprandial , chemistry , catabolism , lipid metabolism , digestion (alchemy) , metabolism , apolipoprotein b , biochemistry , medicine , endocrinology , lipoprotein , biology , cholesterol , chromatography , very low density lipoprotein , adipose tissue , insulin
Objective Because metabolic diseases are characterized by an altered lipid metabolism including prolonged postprandial hyperlipemia, we investigated the impact of using milk polar lipids as emulsifier on lipid digestion and postprandial lipemia. Methods: Mice were gavaged with emulsions stabilized with polar lipids from milk (MPL) vs soybean (SPL). Plasma and small intestine were collected during digestion. Both emulsions were also lipolyzed in vitro using a static human digestion model. Results: In vivo , MPL induced higher plasma concentrations of triglycerides (TG) and unesterified fatty acids (NEFA) than SPL at 1h after feeding. The opposite was observed after 4 h with lower TG in MPL group ( P PLxtime <0.01). This was associated with a lower gene expression of ApoB and Sar1B, which are proteins involved in chylomicron structure and secretion, in the duodenum of MPL vs SPL mice ( P <0.05). Chylomicrons were larger in MPL group at 4 h ( P <0.01). The kinetics of synthesis and/or clearance of chylomicrons thus depended on the type of emulsifier. In vitro , TG hydrolysis from MPL emulsion was faster during intestinal phase than using SPL. This enhanced lipolysis can partly explain the sharper rise of plasma TG at 1 h in MPL group and its subsequent faster decrease. Conclusions Milk polar lipids used as emulsifier can modulate both digestive lipolysis and postprandial lipid metabolism compared to soybean lecithin. Possible long‐term effects in humans will thus deserve further investigations.