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Zeolite supplementation has beneficial effects on gut wall integrity in endurance trained subjects
Author(s) -
Lamprecht Manfred,
Bogner Simon,
WallnerLiebmann Sandra,
Steinbauer Kurt,
Schuetz Burkhard,
Schippinger Gert
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.733.7
Subject(s) - tlr2 , placebo , medicine , zeolite , endocrinology , chemistry , receptor , tlr4 , biochemistry , pathology , alternative medicine , catalysis
Zeolites are crystalline compounds with microporous structures of Si‐tetrahedrons. In the gut, these sicilicates could act as adsorbents, ion‐exchangers, catalysts, detergents or anti‐diarrheic agents. This study evaluated whether Zeolit supplementation could influence biomarkers of gut wall integrity in endurance trained individuals. In a randomized, double‐blinded, placebo controlled trial, 56 endurance trained men and women, similar in body fat, non‐smokers, 20–50 years, received 2g of Zeolith per day for 12 wk. Stool and blood samples for determination of tight junction modulators Zonulin and toll‐like‐receptor 2 (TLR2), as well as antiinflammatory IL‐10 were drawn at the beginning and the end of the study. Nutrition and physical exercise training were standardized before sample collections. For statistical analyses a 2‐factor ANOVA was used. At baseline both groups showed stool zonulin and plasma IL‐10 concentrations above normal. After 12 wk Zeolite supplementation Zonulin was significantly (p<0.05) decreased in the supplemented group. TLR2 in monocytes was significantly increased, and IL‐10 was increased with a trend (p<0.1) in the Zeolite group. Zeolite supplementation exerted beneficial effects on gut wall integrity via modulation of tight junctions. This was accompanied by antiinflammatory effects in this cohort of endurance trained subjects. Further research is needed to explore mechanistic explanations for the observations in this study.