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Differences in Bone Turnover and 25(OH)D Change in Indoor Athletes
Author(s) -
Teager Cassidy,
Redzic Maja,
Cassity Evan,
Thomas D.
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.733.20
Subject(s) - bone remodeling , bone mineral , medicine , n terminal telopeptide , endocrinology , turnover , vitamin d and neurology , alkaline phosphatase , athletes , bone resorption , chemistry , osteocalcin , physical therapy , osteoporosis , biochemistry , enzyme , management , economics
Differences in bone mineral density and bone turnover have been observed in several athlete types. However, athlete bone change in relation to vitamin D status has not been well characterized, especially in low impact sports such as swimming. The purpose of this study was to determine how vitamin D (25(OH)D) status is associated with bone turnover in collegiate swimmers and divers. Over 6 months, body composition (DXA), 25(OH)D, and bone turnover markers [Bone Specific Alkaline Phosphatase (BSAP), and N‐terminal telopeptide (NTx)] were measured (13 female, 19 male; age 19.4±1.4 years). Participants were categorized into high, moderate, or low bone turnover groups at each time point. Mean 25(OH)D at baseline was 57±16ng/mL with an average 6 month change of ‐7.1±15ng/mL. At endpoint, mean BSAP and NTx were 33.4±13.6μg/L and 18.5±5μg/L respectively. At midpoint and endpoint, athletes with the highest rate of bone turnover had significantly different patterns of 25(OH)D change (midpoint: ‐16.5ng/mL; endpoint: ‐16.9ng/mL) compared to athletes with minimal turnover (‐2.2ng/mL, ‐3.3ng/mL; n=22, n=23)(p<.05) without significant differences in weight and body fat. Participants who shifted to a higher bone turnover group (n=5) lost more 25(OH)D than those who shifted to a lower turnover group (n=6; p=.002). These data suggest that monitoring vitamin D status may provide insight on bone turnover independent of body composition changes. Future studies should examine multiple markers of bone turnover to further elucidate the effects of vitamin D status on bone health of athletes. This project was supported by NIH CTSA UL1TR000117.