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Caffeine and Creatine's Combined Effects on Plasma Lactose and Glucose Levels: A Systematic‐Review and Meta‐Analysis
Author(s) -
ShamsWhite Marissa,
Wang Ding Ding,
Chung Mei
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.733.18
Subject(s) - creatine , medicine , meta analysis , anaerobic exercise , sprint , caffeine , placebo , prospective cohort study , endocrinology , physical therapy , pathology , alternative medicine
Objectives: To conduct a systematic review and meta‐analysis evaluating the effects of caffeine and creatine together on blood glucose and lactate levels in healthy adults. Methods: The Medline database was searched through June 2013 for intervention trials and prospective cohort studies in English‐language that utilized both caffeine and creatine supplements in adults. Random effect models meta‐analysis was used when same outcomes were reported in at least two studies. Results: Eleven studies were eligible for the systematic review using the caffeine and creatine combination. The intervention duration ranged from 1‐15 days. Overall, the studies showed improvements in high‐intensity muscle endurance and power and anaerobic sprint performance, but had mixed findings with aerobic training among cyclists. Two all‐male studies were eligible for our meta‐analysis. Lee et al and Ratamess et al administered 0.3g/kg creatine for 5 days and 5 g creatine for 1 day, respectively; both studies administered 110 mg caffeine to subjects on the day of testing.A significant increase was found in plasma lactate (net change 1.37 mmol/L, 95% CI ‐0.04, 2.77, p=0.057) and glucose (net change 0.62 95% CI 0.40, 0.83, p<0.001). Conclusions The combination of caffeine and creatine may improve anaerobic and weight‐lifting performance. Future studies are needed to investigate the possible mechanisms for these supplements' effects on plasma lactate and glucose levels.