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Serum cytokine levels in healthy Mongolian school‐age children randomized to either vitamin D or placebo.
Author(s) -
Davaasambuu Ganmaa,
Enkhbold Yaruuna,
Boldbaatar Ninjin,
Furtado Jeremy
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.729.8
Subject(s) - placebo , cytokine , medicine , vitamin d and neurology , vitamin , placebo group , immunology , randomized controlled trial , gastroenterology , physiology , pathology , alternative medicine
Objective to examine the effects of daily supplements of vitamin D on specific cytokine levels that play a role in the host inflammatory response Methods: Double‐blinded, placebo‐controlled feasibility pilot study among120 healthy Mongolian children in Ulaanbaatar to assigned either to 800IU of vitamin D daily or identical‐looking placebo. The follow‐up was 6 months. We measured levels of 21 different cytokines (IL‐1b, 2, 4, 5, 6, 7, 8, 10, 12p70, 13, 17a, 21, 23, GM‐CSF, IFN‐γ, TNF‐α, ITAC, Fractalkine, MIP1a, MIP1b, MIP3a) in the subsamples of serum of participants at baseline and the follow‐up visit. Results: The baseline 25(OH)D level was 7±4 ng/mL. The cytokine levels were not different between placebo group and vitamin D group at baseline. After 6 month of follow up the cytokine levels were not statistically significant except the levels of Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) between vitamin D and Placebo group post‐treatment (p=0.03). Conclusions Our preliminary data show that vitamin D repletion does not change background T cell parameters in Mongolian school age children although this conclusion is limited by its small sample size and perhaps kit sensitivity issue in measuring cytokine levels in children.