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Antibacterial Evaluation of 2‐oxo‐4‐(phenylamino)‐2H‐chromene‐3‐carbaldehyde
Author(s) -
Govori Sevdije,
Spahiu Sabrie,
Haziri Arben
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.721.6
Subject(s) - enterobacter cloacae , antibacterial activity , pseudomonas aeruginosa , novobiocin , chemistry , aniline , enterobacter , antibacterial agent , microbiology and biotechnology , enterobacteriaceae , antibiotics , bacteria , biology , organic chemistry , biochemistry , escherichia coli , genetics , gene
This study presents the synthesis, spectral analysis and antibacterial evaluation of 2‐oxo‐4‐(phenylamino)‐2H‐chromene‐3‐carbaldehyde (3). Compound (3) was synthesized by action of aniline (a) on 4‐chloro‐2‐oxo‐2H‐chromene‐3‐carbaldehyde (2). The synthesized compound was screened for in vitro test of its antibacterial activity against three bacterial cultures: Hafnia alvei, Pseudomonas aeruginosa and Enterobacter cloacae . The antibacterial activity of synthesized compound was compared to antibacterial activity of novobiocin as standard drug. The biological evaluation of compound (3) generally showed moderate activity against Hafnia alvei, Pseudomonas aeruginosa and Enterobacter cloacae compared with novobiocin.