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Reverse Effect of Coconut Water on Lipidomics of Low Level Cadmium‐Induced Rat
Author(s) -
Ogunrinola Olabisi,
Wusu Adedoja,
Adu Benedict,
Elemo Babajide,
Ademuyiwa Oladipo
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.715.20
Subject(s) - cadmium , distilled water , chemistry , coconut oil , phospholipid , food science , toxicology , zoology , biology , biochemistry , chromatography , organic chemistry , membrane
Coconut water is one of the world natural products with increasing scientific evidence that support the role of coconut water in health and medicinal application. This study was undertaken to investigate the reverse effect of coconut water on the lipid metabolism of cadmium‐induced Wister male albino rats that might result in vascular diseases. Sixty‐four animals were exposed to 100, 200, and 300ppm cadmium doses for 6 weeks in their drinking water, then administered with coconut water for a week. Control animals received distilled water and coconut water for the same period. At the end of 6 weeks, dyslipidemia induced by the cadmium doses exhibited different patterns. Dose‐dependent hypocholesterolemia, hypotriacylglyceridemia and hypophospholipidosis characterized the effect of cadmium exposure at all doses while coconut water ameliorate these effects. Hepatic and brain cholesterol and phospholipid were dose‐dependently decreased by cadmium exposure respectively. While brain triacylglyceride decreased by cadmium exposure, hepatic triacylglyceride was increased dose‐dependently. On the other hand, administration of coconut significantly (p<0.05) enhanced cholesterol, triacylglyceride content and resulted in a fluctuation in phospholipid concentration. Our findings indicate that in contrast to strengthening a dose‐dependent effect phenomenon as observed with many other compounds, cadmium up‐ or down‐regulate different pathways in the lipid metabolism spectrum at “low” or “high” doses and this might be responsible for the insidious vascular effects and the administration of coconut water was able to reverse the damage caused by cadmium intoxication.