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Synthesis and Characterization of Deoxyribonucleic Acid Aptamers for β‐D‐Glucan Carbohydrates
Author(s) -
Webster Nicholas,
Rohlman Christopher
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.710.18
Subject(s) - aptamer , dna , polysaccharide , biochemistry , glucan , rna , carbohydrate , chemistry , biology , computational biology , gene , microbiology and biotechnology
This work explores the use of short randomized single‐stranded DNA aptamers which have the ability to be selected to bind to molecular structures including DNA, RNA, protein, and carbohydrates. This work will focus on the selection of aptamers that show selectivity for the β‐D‐Glucan carbohydrate, a polysaccharide that has many roles in immunity, cholesterol metabolism and infection. This work will act as proof of concept for targeting carbohydrates for future studies.