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Genome Wide Association Study of Dental Arch Form and Occlusal Relationships in the Mixed Dentition Stage
Author(s) -
Miller Steven,
Shaffer John,
Marazita Mary,
Levy Steven,
Warren John,
Hartsfield James,
Moreno Lina
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.697.4
Subject(s) - dental arch , arch , dentition , orthodontics , malocclusion , variation (astronomy) , association (psychology) , etiology , dentistry , medicine , psychology , geography , physics , archaeology , astrophysics , psychotherapist
Dental arch form has been a major subject of investigation in the dental sciences, however, little is known about the genetic etiology of arch form and arch occlusal relationships. This study seeks to examine the potential genetic underpinnings of dental arch form and malocclusion. A sample of n=272 dental casts of the mixed dentition stage (around age 9) were scanned and landmarked to capture data pertaining to dental arches shape and position and then subjected to principal components analysis (PCA) to identify the most important aspects of phenotypic variation. These PC scores were then correlated with whole‐genome association data for a subset of n=210 individuals to identify potential relationships between dental arch form and the genome. Phenotypic variation captured through PCA identified antero‐posterior (AP) discrepancies between the maxillary and mandibular arch (PC1 – 24.2% variation) as well as arch width variation (PC2 – 15.8%) and AP discrepancies with variation in the curve of Spee (PC3 – 14.9%). Suggestive relationships between PRKD1 and PC1 (p=7.11E‐06), RBFOX1 and PC2 (p=8.06E‐06) as well as DACH1 and PC3 (3.27E‐06) were found. This study is among the first to identify variation in dental arch shape and position that may be related to variants in these genes. Support: Carver Charitable Trust #12‐4058 and NIH 2 UL1 TR000442, 1T90DE023520, R01‐DE09551 and U01‐DE018903