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Exercise Training Reduces Cardiac Dysfunction and Remodeling in Ovariectomized Rats Submitted to Myocardial Infarction.
Author(s) -
Abreu Glaucia,
Almeida Simone,
Claudio Erick,
Mengal Vinicius,
Oliveira Suelen,
Carvalho Ana Ligia,
Podratz Priscila,
Merlo Eduardo,
Gouvêa Sônia,
Graceli Jones
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.677.32
Subject(s) - ovariectomized rat , medicine , ventricular remodeling , heart failure , endocrinology , myocardial infarction , oxidative stress , cardiology , cardiac function curve , muscle hypertrophy , diastole , blood pressure , estrogen
To evaluate the effects of exercise training (ET) on cardiac dysfunction and ventricular remodeling in ovariectomized (OVX) rats subjected to myocardial infarction (MI) and the possible mechanisms involved. OVX Wistar rats were subjected to MI or Sham surgery and divided in Control, OVX+SHAM SED , OVX+SHAM ET , OVX+MI SED and OVX+MI ET groups. ET was performed on a treadmill (5x/wk, 60 min/day, 8 weeks). Cardiac function was assessed by ventricular catheterization and DHE fluorescence was evaluated to analyze oxidative stress. Collagen deposition, myocyte hypertrophy and infarct size was assessed by histology. Catalase, SOD‐2, Gp91phox and AT1 receptor (AT1R) expression were evaluated by western blotting. MI‐trained rats had significantly increased in +dP/dt and decreased left ventricular end‐diastolic pressure compared with MI‐sedentary rats. Moreover, oxidative stress and collagen deposition was reduced, as was myocyte hypertrophy. There were a reduction in AT1R and gp91phox expression and an increase in catalase expression. Therefore, ET improves the functional cardiac parameters and attenuates cardiac remodeling associated with a reduction in oxidative stress in OVX rats subjected to MI. Thus, ET may be an important therapeutic target for the prevention of heart failure in postmenopausal women affected by MI.