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Metabolic efficiency during exercise in patients with overlap of obstructive sleep apnea in metabolic syndrome
Author(s) -
Carvalho Jefferson,
Cepeda Felipe,
ToschiDias Edgar,
Rodrigues Sara,
DutraMarques Akothirene,
MakiNunes Cristiane,
Rondon Maria Urbana,
Alves Maria Janiere,
Braga Ana Maria,
Filho Geraldo,
Negrão Carlos,
Trombetta Ivani
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.675.23
Subject(s) - medicine , obstructive sleep apnea , metabolic syndrome , polysomnography , respiratory compensation , endocrinology , cardiology , obesity , apnea , physical therapy , anaerobic exercise
Metabolic syndrome patients (MetS) have increased cardiovascular risk in the presence of obstructive sleep apnea (OSA). Besides decreased peak oxygen consumption (VO 2 peak), the impairment on metabolic efficiency by linear regression (slope) of increases in VO 2 and increases in workload (ΔVO 2 /ΔW) during submaximal exercise test can be used as a marker of worst prognosis. So, we tested the hypotheses that ΔVO 2 /ΔW is decreased in MetS patients and the association of MetS and OSA causes further impairment on VO 2 peak and ΔVO 2 /ΔW. Seventy eight MetS sedentary patients (ATP‐III) without the use of drugs were divided into: MetS+OSA (n=31, 49±2 yrs) and MetS‐OSA (n=30, 46±1 yrs). A control group (C; n=17, 48±2 yrs) was also studied. OSA was determined by apnea/hypopnea index (AHI>15events/h‐polysomnography). The slope ΔVO 2 /ΔW was determined from the 1 st min up to respiratory compensation point during cardiopulmonary exercise testing.The MetS+OSA and MetS‐OSA are similar and had lower ΔVO 2 /ΔW (0.12±0.01, 0.13±0.01 and 0.17±0.01 ml/kg/min/W, p<0.01) and diminished VO 2 peak (22.6±1, 23.6±1 and 26.8±2 ml/kg/min, p<0.05) than C. ΔVO 2 /ΔW was associated with BMI (r=‐0,63, p<0.01), CA (r=‐0,53, p<0.01) and Glucose (r=‐0,53, p<0.01). Independently of presence of OSA, MetS patients have impaired functional capacity and metabolic efficiency during exercise. The excess body fat and insulin resistance seem to be the main causes of these decreases in MetS patients.