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Mean arterial pressure and wave reflection during the cold pressor test: the influence of trunk fat
Author(s) -
Harwood Morton,
Wakeham Travis,
Durocher John
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.650.3
Subject(s) - supine position , mean arterial pressure , trunk , heart rate , cold pressor test , blood pressure , medicine , cardiology , applanation tonometry , arterial stiffness , ecology , biology
Previous work reports that changes in the aortic augmentation index (AIx) are correlated with changes in mean arterial pressure (MAP) during the cold pressor test (CPT) in normal weight adults. The purpose of the present study is to examine the relationship between MAP and AIx responses during CPT in those with high (蠅32%; n=10) and low (蠄 30%; n=10) trunk fat. Trunk fat was determined via bioelectric impedance analysis (Tanita BC‐418). Participants were tested in the supine position during a 3 min baseline and 3 min CPT while MAP and heart rate (HR) were continuously recorded. Radial applanation tonometry measurements were assessed approximately 30 s into each minute, and AIx is reported as a mean of baseline measurements and from the 3 rd minute of CPT (n=7 for each group). Baseline MAP, HR, and AIx were similar in the 2 groups. The increases in MAP (Δ18±3 vs. Δ17±3 mmHg), HR (Δ9±1 vs. Δ4±2 beats/min), and AIx (Δ14±5 vs. Δ9±5%) were similar for the low and high trunk fat groups, respectively. Consistent with previous work the MAP responses to CPT were correlated to changes in AIx across all participants (r=0.70; p<0.01). When separately examining the low trunk fat group, ΔMAP and ΔAIx remained significantly correlated (r=0.87; p<0.01), but in the high fat group the correlation was no longer significant (r=0.43; p=0.33). Our results indicate that while MAP responses to CPT are similar in low and high trunk fat participants, the relationship between ΔMAP and ΔAIx appears to be disrupted by elevated trunk fat.