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Effect of Left Ventricular‐Central Artery Coupling on Cerebrovascular Hemodynamics: Insights from Endurance Training Intervention
Author(s) -
Tomoto Tsubasa,
Sugawara Jun,
Nogami Yoshie,
Aonuma Kazutaka,
Maeda Seiji
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.645.9
Subject(s) - pulsatile flow , cardiology , medicine , cerebral blood flow , middle cerebral artery , hemodynamics , blood flow , compliance (psychology) , transcranial doppler , stroke volume , ejection fraction , ischemia , heart failure , psychology , social psychology
Increased pulsatile fluctuation of cerebral blood flow may mechanically impact on vulnerable brain tissue. The aim of this study was to investigate participation of central artery damping function on pulsatile blood flow transmission from LV to the brain using the endurance training intervention study design. We measured maximal oxygen uptake (VO 2max ), LV ejection velocity (via ultrasound), carotid arterial compliance (via ultrasound and applanation tonometory), and middle cerebral arterial (MCA) hemodynamics (via transcranial Doppler) before and after 16‐week endurance training in 13 collegiate tennis players. After the intervention, VO 2max was significantly increased ( P <0.01). Despite a significant increase in LV ejection peak velocity ( P <0.05), MCA blood flow (i.e., peak and mean flow velocity, pulsatility index) were remained unchanged ( P =0.854). Carotid arterial compliance was improved after the intervention ( P <0.01) and individual changes were correlated with the corresponding changes in MCA pulsatility index (r=‐0.584, P <0.05). These results suggest that because of the contribution of increased central arterial compliance, cerebral pulsatile flow fluctuation was not augmented even when LV ejection was increased by endurance training.