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Coronary Blood Flow is Reduced by Doxorubicin: a Ultrasound Microscopic Study
Author(s) -
Liu Shi
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.644.1
Subject(s) - parasternal line , blood flow , cardiotoxicity , ventricle , doxorubicin , medicine , cardiology , diastole , cardiac function curve , ultrasound , doppler echocardiography , blood pressure , heart failure , toxicity , chemotherapy , radiology
The use of doxorubicin (DOX), an anti‐cancer drug, in treatment for various malignancies is limited because of its cardiotoxicity; whether DOX causes vascular disorders is unknown. Ultrasound biomicroscopy (UBM) has been a valuable, non‐invasive technique in monitoring cardiac function but not commonly used in small animal vascular studies.This study aimed to 1) study the velocity of blood flow in the left coronary artery (LCA) under physiological conditions and vascular responsiveness to DOX treatment with UBM, and 2) examine the effect of an aqueous extract of TA bark ( TA AqE ), a cardiotonic, on the blood‐flow velocity of LCA after DOX treatment. Young adult mice were injected intrapleurally with a single dose of DOX (20 mg/kg) or saline in the presence or absence of TA AqE . Doppler UBM was performed the day before and 1 week after DOX treatment using Vevo®2100. The blood flow of LCA and left ventricle (LV) function were monitored in the parasternal short‐axis view of UBM. The peak blood‐flow velocity of LCA during cardiac diastole and systole was 909±35 and 284±13 mm/s, respectively, (n=20) without drug treatment. Abnormality of LV function could be detected in the 1 st week and was increased rapidly in the 2 nd week of DOX treatment. Meanwhile, the integrated blood flow of LCA was reduced about 42% (n=9) accompanied by an increase in the resistive index by 85%. Pretreatment of TA AqE offset the detrimental effects of DOX on LCA and LV function. In summary, 1) DOX caused reduction in LCA blood‐flow velocity besides cardiotoxicity, and 2) TA AqE offered some cardiovascular protective effects. In conclusion, Doppler UBM is very useful in detecting longitudinal hemodynamic changes of LCA. The DOX‐induced decrease in blood‐flow velocity of LCA could result from reduction in the blood flow and/or vasoconstriction.