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Therapeutic efficacy of cerium oxide nanoparticles against sepsis induced acute lung injury
Author(s) -
Arvapalli Ravikumar,
Manne Nandini,
Rice Kevin,
Blough Eric
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.620.14
Subject(s) - sepsis , cerium oxide , oxidative stress , immune system , medicine , reactive oxygen species , pharmacology , myeloperoxidase , inflammation , nitric oxide , hypoxia (environmental) , chemistry , immunology , oxide , oxygen , biochemistry , organic chemistry
Sepsis induced acute lung injury (ALI) is one of the leading causes of mortality in the intensive care unit. The development of ALI is primarily driven by the systemic inflammatory response syndrome and the increased cellular ROS subsequent to immune system over activation. Cerium oxide nanoparticles (CeO 2 ) nanoparticles have been shown to scavenge reactive oxygen species both in vitro and in vivo under various experimental settings while others have suggested that they may also exhibit the ability to protect lungs from hypoxia induced oxidative stress. In the present study we investigated the protective effects of cerium oxide nanoparticles against sepsis induced ALI. Administration of a single dose of CeO 2 nanoparticles (0.5mg/kg) to septic animals attenuated alveolar congestion. Treatment associated decreases in alveolar congestion were associated with reduced infiltration of inflammatory cells, diminished myeloperoxidase activity, and decreased p38‐MAPK / STAT3 phosphorylation. Additional experiments to explore the potential efficacy of using CeO 2 nanoparticles for the treatment of sepsis induced ALI may be warranted.