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Role of SLMAP Genetic Variants in Susceptibility of Diabetes and Diabetic Retinopathy in Qatari Population
Author(s) -
Upadhyay Rohit,
Crystal Ronald,
Ding Hong
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.619.9
Subject(s) - diabetic retinopathy , genotyping , medicine , type 2 diabetes , diabetes mellitus , single nucleotide polymorphism , snp , haplotype , population , polymorphism (computer science) , endocrinology , genotype , genetics , gene , biology , environmental health
Objective Overexpression of SLMAP gene has been associated with diabetes and endothelial dysfunction of macro‐ and micro‐blood vessels. In this study, our primary objective is to explore the role of SLMAP gene polymorphisms and genetic variants of SLMAP in the susceptibility of type 2 diabetes, with or without type 2 diabetes associated retinopathy (DR), in the Qatari population. Research design and methods A total of 341 Qatari subjects (non‐diabetic controls and type‐2 diabetic patients with or without diabetic retinopathy) were genotyped for SLMAP gene polymorphisms (rs17058639 C>T; rs1043045 C>T and rs1057719 A>G) usingTaqman SNP genotyping assay. Results SLMAP rs17058639 C>T polymorphism was associated with the presence of diabetic retinopathy among Qataris with type 2 diabetes. One‐way ANOVA and multiple logistic regression analysis showed SLMAP SNP rs17058639 C>T as an independent risk factor for DR development. SLMAP rs17058639 C>T polymorphism also had predictive role for severity of DR. Haplotype C rs17058639 Trs1043045Ars1057719 was associated with the increased risk for DR among Qataris with type 2 diabetes. Conclusions The data suggests the potential role of SLMAP SNPs as a risk factor for the susceptibility of DR among type 2 diabetes patients in Qatari population.