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Evaluation of the Anti‐Inflammatory and Analgesic Activities of Leaf‐Extracts of Sterculia tragacantha in Rats
Author(s) -
Abatan Matthew,
Mogbojuri Olufunke
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.616.5
Subject(s) - chloroform , chemistry , analgesic , anti inflammatory , aqueous extract , pharmacology , dose dependence , traditional medicine , chromatography , medicine
Pilot toxicity studies using 200, 1000 and 3000 mg/kg doses of the aqueous extract of Sterculia tragacantha in albino rats did not produce significant (P< 0.05) adverse effects on haematological and biochemical parameters. Doses of the chloroform extract at 100 and 200 mg/kg caused inhibition of increase in paw volume at 1 hr (9.9%), 2 hrs (10.7%) and 3hrs (14.0%); whereas the 200mg/kg dose caused 1 hr (13.4), 2 hrs (16.4) and 3hrs (20.6%) inhibition in paw oedema. Evaluation of the n‐hexane extract of S. tragacantha produced 53.9 and 68.8% inhibition of writhing pain at 100 and 200 mag/kg doses respectively; the 100 and 200 mg/kg doses of the chloroform extract also produced 50 and 79.3% inhibition writhing pain respectively. Pooled chromatographic fractions of the chloroform extract with common Rf gave crystals which when tested at 25mg/kg dose gave a 35.4% inhibition of inflammation whereas the same dose produced 79.1% inhibition of writhing pain. Gas chromatographic mass spectrum analysis of the chloroform extract revealed the bioactive compounds to be n‐hexadecanoic acid, 9‐octadecanoic acid and n‐triacontane. It is concluded that the chloroform extract of S. tragacantha possesses anti‐inflammatory and analgesic properties which may account for the medicinal use.