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The Soy Tofu By‐product, Biji, Ameliorates High Fat Diet‐induced Obesity in C57BL/6J Mice
Author(s) -
Kim Hyun Suk,
Yu Ok Kyeong,
Byun Moon Sun,
Cha Youn Soo
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.608.13
Subject(s) - obesity , leptin , food science , chemistry , ingredient , medicine , isoflavones , endocrinology , soy protein , blood lipids , cholesterol
Biji is a soybean by‐product left over after straining soy milk when making tofu; it has a high water content making it vulnerable to spoilage. However, Biji contains significant amount of dietary fiber and protein as well as considerable amounts of isoflavones and mineral elements, making it a suitable functional ingredient with health promoting attributes. Therefore, this study aimed to validate the anti‐obesity effect of biji in diet induced obese mice. Thirty two C57BL/6J male 4 week old mice were divided into four groups (n=8) and were fed for 12 weeks with normal diet (ND), high‐fat diet (HD), HD with 10% Biji (BL), or HD with 20% Biji (BH). After sacrifice, blood and liver samples were collected for analyses of hepatic and serum lipid profiles, along with serum insulin and leptin. The results showed that the food intake was not significantly different among the four groups, but the food efficiency ratios (FER) of BH and ND were significantly lower than HD and BL. Body weight gain and body fat mass were lower in ND and BH compared to HD. Furthermore, a significantly lower level of serum TG and TC was noted in BH and ND which were more pronounced than HD. Serum insulin levels of BH and ND were also significantly lower than HD. Similarly, the leptin level of BH, BL, and ND were significantly lower than HD. In conclusion, Biji appears to contribute beneficial effects on ameliorating anthropometric attribute as well as biomarkers related to obesity, however this study did not elucidate the changes in the expression of hepatic lipid metabolic genes, therefore further studies evaluating its effects on gene expression will be conducted.