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Dietary Fat Composition Effects on Postprandial Systemic Markers of Inflammation and Metabolism
Author(s) -
Lyte Joshua,
Hollis James,
Gabler Nick
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.607.14
Subject(s) - postprandial , meal , polyunsaturated fatty acid , inflammation , medicine , systemic inflammation , triglyceride , endocrinology , saturated fat , food science , chemistry , fatty acid , biochemistry , cholesterol , insulin
Dietary fat is a potential mediator of metabolic disease although the mechanisms responsible have yet to be fully elucidated. n‐3 polyunsaturated fatty acids may reduce the risk of developing metabolic disease by attenuating postprandial endotoxemia and inflammation. The objective of this study was to determine if a meal's fatty acids composition influenced postprandial serum and plasma markers of inflammation. We hypothesize that consuming meals containing n‐3 fatty acids will reduce systemic markers of postprandial inflammation compared to meals enriched in n‐6 or saturated fatty acids. Adult participants (n=31) were required to report to the lab on four separate occasions. Then, an indwelling catheter was inserted and a baseline blood draw collected. Participants then ate one of the four test meals that provided 1) 20% fat or 35% fat with 2) n‐3 3) n‐6 or 4) saturated fat. Pre‐ and postprandial blood samples were collected over a 5 hour period. Serum and plasma were analyzed for metabolites and biomarkers of acute systemic inflammation and endotoxin. Data was analyzed using repeated‐measures ANOVA. There was no statistically significant effect of meal fat content on serum concentration of triglyceride, C‐reactive protein or other metabolites (p < 0.05). Differences in the fat composition of a meal did not influence postprandial concentrations of the measured markers of inflammation. Ongoing evaluation of samples to determine endotoxin content will examine a potential role for fatty acids in modulating postprandial endotoxemia.