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Profile of Gallic Acid Metabolites in Urine After the Intake of Mango ( Mangifera indica, L. ) cv. Keitt in Humans.
Author(s) -
Barnes Ryan,
Krenek Kimberly,
Talcott Susanne,
Talcott Stephen
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.606.13
Subject(s) - gallic acid , chemistry , metabolite , urine , mangifera , polyphenol , food science , chromatography , biochemistry , botany , biology , antioxidant
The polyphenolic profile of mango is mainly based on gallic acid derivatives. The biological activity of gallic acid is well established, however effects of absorption and metabolism are widely under investigated. Chemical characterization and assessment of biological activities of gallic acid metabolites will provide the basis to conduct clinical trials with a high relevance for public health. This study investigated gallic acid metabolites after consumption of 400 grams of mango cv. Keitt in 10 healthy volunteers over 12 h. For the first time, 6 urinary, gallic acid metabolites were identified indicating the absorption of gallic acid derived from gallic acid glycosides. O‐ methylgallic acid‐ O ‐sulfate was identified as the major metabolite 0‐6 hours post consumption at an average concentration of 0.396 mg/ 10mg urinary creatinine, followed by O‐ methylgallic acid at 0.012 mg/ 10mg urinary creatinine. Colonic metabolites (pyrogalloyl derivatives) were detected in urine after 3‐6 h. Results indicate absorption and metabolism of gallic acid derivatives in humans where colonic metabolites are absorbed via enterohepatic circulation.