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Uncertain Effects of Beta‐Carotene Supplementation on Oxidation: a Meta‐Regression Analysis of Lag Time to Absorption
Author(s) -
Vecchio Maria Gabriella,
Minto Clara,
Gregori Dario
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.603.3
Subject(s) - lag time , beta carotene , carotene , meta analysis , medicine , analysis of variance , lag , population , chemistry , zoology , biology , vitamin , food science , computer network , environmental health , computer science , biological system
Background β‐carotene has the capability to delay oxidative processes having beneficial effects in preventing cancer and CVDs. The aim of this study was to evaluate, through a meta‐analysis of clinical studies, the association between β‐carotene supplementation and lipid oxidation
Methods Articles published until September 2014 were collected using Pubmed.The search string was “Vitamins” limited to “clinical trials” and “humans”.18091 records were retrieved.Out of them,studies with detailed information of dose of β‐Carotene,Lag Time and Duration were retrained for the analysis.A meta‐regression model for Lag Time and another separate for Maximal Oxidation Rate(MOR)has been estimated using Generalized Least Squares, accounting for within‐study correlation (assuming a Continuous Auto‐Regressive of first order structure) and weights proportional to study variance and study size.Effect of dose has been estimated as Cumulative Effect (Dose per day over the weeks of study duration)
Results 9 studies (465 subjects) were included in the meta‐analysis for Lag Time evaluation (5 collected also information on MOR).Susceptibility of LDL to metal ions‐mediated oxidation in vitro was assessed by measuring conjugated diene formation at 234 nm.No significant dose‐response relationship has been found between β‐carotene supplementation and Lag Time and MORN. Studies Effect S.E. p‐valueDose on Lag Time(min) 9 0.00603 0.004026 0.1491Dose on MOR(nmol/mg LDL protein/min) 5 ‐0.00007383 0.0004117 0.8621Conclusions β‐carotene supplementation may not have beneficial effects on lipid oxidation in healthy population.Given the high variability in study estimates and the promising meta‐effect,although not strictly significant,further studies are necessary to confirm these conclusion