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Lycopene Supplementation and Oxidation: a Metaregression Analysis of Lag Time to Absorption
Author(s) -
Minto Clara,
Vecchio Maria Gabriella,
Gregori Dario
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.603.2
Subject(s) - lycopene , medicine , lag time , population , meta analysis , gastroenterology , carotenoid , chemistry , biology , food science , environmental health , biological system
Background LDL oxidation plays an important role in the pathogenesis of CVD and carotenoids could be related to decreased susceptibility of this oxidation.Several authors have suggested that Lycopene supplementation may have beneficial effects on LDL oxidation.This study evaluates the association between Lycopene addition and mean of lag time oxidation through a meta‐analysis of 3 intervention trials Methods Relevant articles published until September 2014 were collected using electronic database PubMed.The search string was “vitamins”, limited to “clinical trials” and “humans”.18091 records were retrieved.Out of them, studies with detailed information of dose of Lycopene, Lag Time and Duration were retrained for the analysis.A metaregression model has been estimated using Generalized Least Squares, accounting for within‐study correlation (assuming a Continuous AutoRegressive of first order structure) and weghts proportional to study variance and study size. Effect of dose has been estimated as Cumulative Effect (Dose per day over the weeks of study duration) Results 90 patients were included in the analysis,receiving different doses of Lycopene.Study Population N Duration Dose Lag Time (min) mean ± SDHininger:2013 Males non smokers 51 12 weeks 15 mg/d LP Week 0 Week 12healthy106± 7,37 95,9±7,53Bub:2000 Males non smokers 23 2 weeks 40 mg/d LP 0‐2 week 2‐4 weekhealthy106±13,4 124±9,9Carrol:2000 males and females 16 12 weeks 13,3 mg/d LP baseline after 12 weekshealthy54±20 62±22Susceptibility of LDL to metal ions‐mediated oxidation in vitro was assessed by measuring conjugated diene formation at 234 nm.A significant dose‐response relationship has been found between cumulative dosage of Lycopene and Lag Time(effect 0.01085,S.E. 0.000908,p<0.001) Conclusions Data suggest that a high‐dose of Lycopene decreases lag time.This result support the assumption that Lycopene supplementation could be protective from diseases related to LDL oxidation