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Effect of Defatted Pepper Seed Extracts on High‐fat Diet‐induced Obesity in Mice
Author(s) -
Sung Jeehye,
Lee Junsoo
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.602.6
Subject(s) - endocrinology , medicine , ampk , obesity , adipose tissue , triglyceride , adipocyte , acetyl coa carboxylase , cholesterol , amp activated protein kinase , weight gain , protein kinase a , biology , chemistry , kinase , body weight , biochemistry , pyruvate carboxylase , enzyme
Obesity is one of the most common metabolic syndromes and poses a major worldwide threat to human health. Recently, natural agents that may be beneficial for improving obesity have received increasing attention. In this study, we investigate the antiobesity effect of defatted pepper seed extracts (DPSE) in diet‐induced obese mice. Male C57BL/6J mice were fed a normal diet (ND) or high fat diet (HFD) with or without DPSE (10, 50 and 100 mg/kg body weight) for 7 weeks. Body weight and food efficiency ratio of mice fed HFD plus DPSE were dose‐dependently decreased compared to those in HFD. Epididymal adipose tissue and liver weights were significantly lowered in mice fed HFD plus DPSE compared to those in HFD. DPSE also lowered triglyceride and cholesterol concentration in plasma. Moreover, DPSE also significantly reversed the HFD‐induced elevation of the expression of the key adipocyte differentiation regulator in the adipose tissue. Furthermore, DPSE resulted in increased phosphorylation of AMP‐activated protein kinase (AMPK) and acetyl‐CoA carboxylase (ACC) in the liver. These results suggest that DPSE may have excellent hypolipidemic potential to prevent obesity.