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Body weight status are associated with biomarkers of inflammation and bone turnover in former smokers
Author(s) -
Lee Sang Gil,
Vance Terrence,
Hurbert Patrice,
Xie Liyang,
Kim Bohkyung,
Lee Jiyoung,
Boling Bradley,
Lee SunKyeong,
Chun Ock K.
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.602.16
Subject(s) - medicine , bone remodeling , adiponectin , inflammation , body mass index , endocrinology , obesity , systemic inflammation , oxidative stress , physiology , gastroenterology , insulin resistance
Smoking, aging and obesity are associated with oxidative stress, inflammation, and chronic diseases. Former and current smokers have greater oxidative stress and inflammation compared with non‐smokers. However, there is limited evidence on how this is affected by demographic, lifestyle, and clinical risk factors. Thus, we investigated the relationship between age, BMI and pack‐year, and biomarkers of oxidative stress, inflammation, cardiovascular disease, and bone disorder in 49 healthy former smokers aged 25 to 60 years . In the multiple linear regression analysis, a 1 unit increase in BMI was associated with a change in fasting plasma IL‐6 of ‐6.3% ( 95% CI ‐9.12, ‐0.56), CRP of 6.1% (95% CI 0.56, 11.83), IL‐1β of ‐ 9.1% (95% CI ‐13.63, ‐4.40), adiponectin of ‐4.7% (95% CI ‐8.91, ‐0.27), bone‐specific alkaline phosphatase (BSAP) of ‐6.5% (95% CI ‐11.15, ‐1.52), and urinary N‐telopeptide of type I collagen (NTX1) of ‐6.1% (95% CI ‐10.93, ‐1.09). However, pack‐year and age did not alter these biomarkers in our study. Our findings indicate that BMI is associated with the inflammation and bone turnover of former smokers. IL‐6 and IL‐1β were negatively correlated with BMI. The association between BMI and bone turnover was less clear, with both BSAP and NTX1 inversely associated with BMI. Therefore, further research is warranted to investigate the relationship between BMI and inflammation and bone turnover in former smokers. Funding: the Nutricia Research Foundation and CT Department of Public Health Biomedical Research Program