Premium
Maternal Serum Fatty Acids are Positively Associated with Systolic Blood Pressure Changes during Pregnancy: Longitudinal Study.
Author(s) -
Farias Dayana,
Rebelo Fernanda,
Eshriqui Ilana,
Lepsch Jaqueline,
Pinto Thatiana,
FrancoSena Ana,
Lima Natália,
Kac Gilberto
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.598.19
Subject(s) - medicine , pregnancy , blood pressure , polyunsaturated fatty acid , prospective cohort study , preeclampsia , anthropometry , gestational age , endocrinology , diastole , obstetrics , fatty acid , chemistry , biology , biochemistry , genetics
Aim To evaluate if maternal serum Fatty Acids (FAs) are associated with Systolic (SBP) and Diastolic (DBP) blood pressure changes during pregnancy. Methods Prospective cohort of 225 healthy pregnant women followed at all pregnancy trimesters: 5 th ‐13 th , 20 th ‐26 th and30 th ‐36 th weeks. SBP and DBP (mmHg) were measured twice at each follow‐up visit using an automatic sphygmomanometer (Omron HEM‐742 INT). The mean values at each trimester were used. Blood samples were collected after 12 hours of fasting. Serum FAs (µg/ml) were evaluated by a high‐throughput robotic direct methylation coupled with fast gas‐liquid chromatography. Longitudinal linear mixed‐effects models were adjusted for gestational age, socio‐economic, demographic, lifestyle, biochemical and anthropometric variables. Results We observed a positive and significant association of total saturated (β=0.004; 95% CI: 0.001‐0.008), monounsaturated (β=0.004; 95% CI: 0.0003‐0.009) and polyunsaturated n‐6 (β=0.005; 95% CI: 0.001‐0.009) FAs with SBP levels during pregnancy. The following fractions were associated with SBP: 16:0 (β=0.005), 18:0 (β=0.040), 20:0 (β=0.746), 16:1 n‐7 (β=0.028), 18:1 n‐7 (β=0.047), 18:1 n‐9 (β=0.006), 18:2 n‐6 (β=0.005), 20:3 n‐6 (β=0.046) (all p‐values<0.05). We did not observe significant associations between FAs and DBP and between polyunsaturated n‐3 FAs and BP changes during pregnancy. Conclusion Maternal serum concentrations of saturated, monounsaturated and polyunsaturated n‐6 FAs were positively associated with SBP changes during pregnancy. Support: CNPq and FAPERJ