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Serum Biomarkers of Dietary Fatty Acids are Associated with Abdominal Obesity Measures in a Large Population‐based Cohort of Men and Women.
Author(s) -
Alsharari Zayed,
Marklund Matti,
Hellénius MaiLis,
Laguzzi Federica,
Gigante Bruna,
Leander Karen,
Sjögren Per,
Cederholm Tommy,
Faire Ulf,
Risérus Ulf
Publication year - 2015
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.29.1_supplement.598.16
Subject(s) - waist , medicine , abdominal obesity , linoleic acid , anthropometry , palmitic acid , population , obesity , waist–hip ratio , polyunsaturated fatty acid , endocrinology , cohort , fatty acid , physiology , chemistry , biochemistry , environmental health
Recent feeding trials suggest that the major saturated fatty acid (FA) Palmitic acid (PA, 16:0) and the major polyunsaturated FA linoleic acid (LA, 18:2n‐6) has diverse effects on abdominal fat accumulation, suggesting a beneficial role of LA on fat deposition. Objective To investigate associations between these FAs assessed in serum cholesterol esters (CE) and anthropometric measures of abdominal obesity. Methods LA and PA were measured by gas chromatography in serum CE. Sagittal abdominal diameter (SAD), waist circumference (WC), and waist‐hip ratio (WHR) were assessed by anthropometry in a population‐based cross‐sectional study of 3965 (1920 men and 2045 women) 60‐year old participants living in Stockholm county, Sweden. Results PA was positively correlated with SAD, WC, and WHR in men ( r = 0.15, 0.16, and 0.14, respectively; all p ˂0.001), whereas inverse correlations were observed for LA in both men ( r = ‐0.23, ‐0.22, and ‐0.22, respectively; p ˂0.001) and women ( r = ‐0.15, ‐0.18, and ‐0.18, respectively; p ˂0.001).Overall, these associations remained after adjusting for lifestyle factors. Conclusions Linoleic Acid was consistently inversely associated with all abdominal obesity measures in both men and women. Palmitic Acid showed positive correlations in men only. These findings support recent interventional data suggesting that a higher relative intake of dietary LA from vegetable oils is associated with decreased abdominal adiposity.